Issues on sedating mental patients
If concomitant use cannot be avoided, patients should be monitored for potentially excessive or prolonged CNS depression and constipation; Corticosteroids: Steroid-induced glaucoma may develop with topical, inhaled, oral or intravenous, steroid administration.
Concomitant use may result in increased intraocular pressure via an open- or a closed-angle mechanism; Medicinal products with anticholinergic properties (e.g.
Caution should be exercised in children with compromised blood brain barrier eg. The effects of glycopyrronium on the reproductive system have not been investigated.
Whilst clinical studies do not report any short or long-term effect of glycopyrronium on neurodevelopment or growth, no studies have been conducted to specifically address these issues.
There are limited data available relating to interactions with other medicinal products in the paediatric age group.
Glycopyrronium should be used with caution in patients with acute myocardial infarction, hypertension, coronary artery disease, cardiac arrhythmias and conditions characterised by tachycardia (including thyrotoxicosis, cardiac insufficiency, cardiac surgery) due to the potential increase in heart rate, blood pressure and rhythm disorders produced by its administration.Dosing should be at least one hour before or at least two hours after meals or at consistent times with respect to food intake. Where the child's specific needs determine that co-administration with food is required, dosing of the medicinal product should be consistently performed during food intake.Nasogastric / feeding tubes, if used, should be flushed with 10 ml water immediately after dosing. ), including those with end-stage renal disease requiring dialysis.Given the limited long-term safety data available and the uncertainties around the potential risk for carcinogenicity, total treatment duration should be kept as short as possible.If continuous treatment is needed (eg in a palliative setting) or the treatment is repeated intermittently (e.g.